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Yes, it is known, that irritation of the circadian "inner clock" is causing some sort of permanent jet lag with deteriorating effect on your immune system, which gives pathway to chronic diseases including various kinds of cancer- but why would the LED retrofit light bulb industry not switch to harmless 365nm near UVA LED stimulus for the spectral conversion phosphors or quantum dots to cure these harmful "side effects"? It might somewhat limit the energy efficiency grade labeling of the light bulbs since the blue light could no longer contribute to the spectral light yield but what is more important - health or marginal electric energy savings? (see my 2015 German article https://www.all-electronics.de/elektronik-entwicklung/kommt-das-gluehlampenverbot-zu-frueh.html)

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